Table 2 The anticancer activities of lycorine and lycorine hydrochloride in vivo

Breast cancer

Nude mice^a

MDA-MB-231

5, 10 mg/kg/day for 30 days, i.p.

Tumor growth inhibition rates were about 60%, 70%

[42]

Nude mice

4T1

5, 10 mg/kg/day for 21 days, i.p.

Tumor growth inhibition rates were about 40%, 50%

Nude mice

MDA-MB-231

5 mg/kg/day for 21 days, i.p.

Lung metastasis inhibition rate was about 80%

Breast cancer

BALB/c mice

4T1/Luc

5, 15 mg/kg/day for 28 days, i.p.

Tumor growth inhibition rates were about 30%, 50%

[36]

Breast cancer

Nude mice

MDA-MB-231

10 mg/kg/day for 18 days, i.p.

Tumor growth inhibition rates were about 75%

[43]

Bladder cancer

Nude mice

T24

5, 10 mg/kg/day for 14 days, i.p.

Tumor growth inhibition rates were 63.50%,74.21%

[40]

B-cell acute lymphoblastic leukemia

NCG mice

NALM-6

10, 20 mg/kg/bid for 21 days, i.p.

Tumor growth was significantly inhibited

[44]

Colorectal cancer

BALB/c mice

CT26

20 mg/kg/day for 14 days, i.p.

Tumor growth inhibition rate was about 65%

[33]

Colorectal cancer

BALB/c mice

CT26

10, 40 mg/kg/day for 14 days, i.v.

Suppressed lung metastasis to 60.99% and 54.14%

[46]

Colorectal cancer

BALB/c nude mice

SW480

20 mg/kg/day for 33 days, i.p.

Tumor growth inhibition rate was about 65%

[102]

Gastric cancer

Nude mice

Patient -derived tissue

Lycorine hydrochloride (30 mg/kg) + HA14–1 (2.5 mg/kg) for 13 days, N/A

Tumor growth inhibition rate was about 70%

[47]

Glioblastoma

BALB/c nude mice

U251-luc

10, 20 mg/kg/day for 40 days, i.p.

Tumor growth inhibition rates were 87.20%, 97.98%

[54]

BALB/c nude mice

Patient-derived glioblastoma multiforme cell

10, 20 mg/kg/day for 14 days, i.p.

Tumor growth inhibition rates were 54.72%, 75.14%

Liver cancer

BALB/c nude mice

Huh7

Lycorine 10 mg/kg/day for 30 days, i.g.

Tumor growth inhibition rate was about 25%

[37]

Sorafenib 30 mg/ kg/day for 30 days, i.g…

Tumor growth inhibition rate was about 60%

Lycorine 10 mg/kg/day + Sorafenib 30 mg/ kg/day for 30 days, i.g.

Tumor growth inhibition rate was over 90%

Liver cancer

C57BL/6 mice

H22

10 mg/kg every 2 days for 18 days, i.p.

Tumor growth inhibition rate was about 60%

[78]

Liver cancer

BALB/c nude mice

HepG2

10,20 mg/kg/day for 33 days, i.p.

Tumor growth inhibition rates were about 50%, 33%

[51]

Leukemia

BALB/c SCID mice

HL-60

5, 10 mg/kg/day on day 2 to 6 and day 14 to 18, i.p.

Decrease the percentages of immature granular leukocytes and monocytes among the peripheral blood cells, prolong survival period

[137]

Lung cancer

BALB/c nude mice

A549/Luc

2.5,5 mg/kg every 2 days for 28 days, i.p.

Tumor growth inhibition rates were 71.04%, 82.27%

[56]

Lung cancer

Nude mice

SPC-A-1

10 mg/kg/day for 28 days, i.p…

Tumor growth inhibition rate was over 75%

[55]

A549

10 mg/kg/day for 34 days, i.p.

Suppressed lung metastasis significantly

Melanoma

NOD/SCID mice

A375

30 mg/kg/day for 25 days, i.p.

Tumor growth inhibition rate was about 50%

[58]

30 mg/kg/day for 40 days, i.p.

Lung metastasis inhibition rate was about 75%

Melanoma

Nude mice

C8161

10 mg/kg/day for 28 days, i.p.

Lung metastasis inhibition rate was about 40%

[68]

Myeloma

NOD/SCID mice

MM.1S

Lycorine 5 mg/kg on day 1,2,3,5,6,7,9,10,11, i.p.

Tumor growth inhibition rate was 48.06%

[61]

BTZ (1 mg/kg/ every 4 days for 11 days), i.p.

Tumor growth inhibition rate was 41.41%

Lycorine 1 mg/kg on day 2, 3, 6, 7, 10, 11 + BTZ 0.25 mg/kg on day 1, 5, 8, i.p.

Tumor growth inhibition rate was 73.53%

Ovarian cancer

BALB/C nude mice

Hey1B

15 mg/kg/day for 24 days, i.p.

Tumor growth inhibition rate was 61.64%

[66]

Pancreatic cancer

C57BL/6 mice

PAN02

5,10 mg/kg for 20 days, i.p.

Tumor growth inhibition rates were about 75%, 85%

[34]

Prostate cancer

C57/BL mice

RM-1

5, 10 mg/kg/day for 14 days, i.g.

Tumor growth inhibition rates were about 40%, 50%

[72]