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Fig. 6 | Chinese Medicine

Fig. 6

From: The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation

Fig. 6

mSMG alleviated IR, promoted glycogen synthesis, and inhibited TNF-α/JNK1/IRS-2 pathway in liver of KK-Ay mice. A Representative H&E and Oil Red O staining images of liver sections (magnification 200×). B NAFLD activity score. C Positive area percentage of Oil Red O staining images. D Glycogen content in liver. E Glycogen synthase activity. F–L mSMG reduced the expression of TNF-α protein and the phosphorylation of JNK1 and IRS-2 (Ser388), and promoted the phosphorylation of Akt (Ser473) and GSK-3β (Ser9) as well as the expression of GLUT2 protein in liver. Data are expressed as mean ± SD (n = 6, *P < 0.05, **P < 0.01, ***P < 0.001)

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Chinese Medicine

ISSN: 1749-8546

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