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Table 2 Nine hub targets identified by 3 topological algorithms in the PPI network

From: The improvement of modified Si-Miao granule on hepatic insulin resistance and glycogen synthesis in type 2 diabetes mellitus involves the inhibition of TNF-α/JNK1/IRS-2 pathway: network pharmacology, molecular docking, and experimental validation

Target symbol

Encoded protein

Degree

Closeness

Betweenness

TNF

TNF-α

37

86.86667

1038.86446

EGFR

EGFR

36

86.78333

1405.93938

CASP3

CASP3

35

87.33333

1592.75902

RELA

NF-κB p65

32

84.66667

1298.52202

GAPDH

GAPDH

32

84.33333

1192.99561

FOS

c-Fos

28

81.83333

1020.78267

MAPK8

JNK1

28

81.03333

845.77760

PTGS2

COX-2

25

79.23333

1712.10864

PPARG

PPAR-γ

24

80.50000

976.27373

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Chinese Medicine

ISSN: 1749-8546

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