Fig. 2
From: The role of natural products targeting macrophage polarization in sepsis-induced lung injury
Potential molecular mechanisms of macrophage polarization during the three phases of SALI. The overwhelming inflammatory stage, the immune suppression stage, and the fibrosis stage, respectively. Among them, the overwhelming inflammatory stage was dominated by M1 phenotype activation, the immune suppression stage was dominated by M2 phenotype activation, and the fibrosis stage was associated with both M1 phenotype and M2 phenotype