A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization

Chinese Medicine

Table 1 Application examples of high throughput screening techniques

Method	Drug library	Total drugs	Screening quantity	Screening drugs	Disease	Refs.
HTS	Compound library	430,376	378	RU-0415529	SARS-COV-2	[157]
	Small Molecule Libraries	3100	74	(S)-amlodipine besylate	Craniopharyngioma	[158]
	Marine compound library	200	1	Naamidine J	Hepatitis B	[159]
	The HTS customized library	2097	16	Panobinostat	Pituitary neuroendocrine tumors	[160]
	lead-like compound library	1280	8	LMK 235, PI 828, Pyroxamide et al	Medulloblastoma	[161]
	Compound library	3.8 million	392	BAY-593	Breast cancer	[162]
	FDA library	2625	1	Baicalin	Acute ischemic stroke	[163]
	Compound library	137,585	19	Morpholine series and Sulfonylamine series	Tuberculosis	[164]
	purchased from Selleck	227	5	Cepharanthine	Japanese encephalitis	[165]
	FDA-approved drugs	1622	1	Albendazole	Tumor	[166]
	herb extracts	578	20	Ginsenoside F2	Hepatocellular carcinoma	[167]
	Spectrum Collection library	2400	9	Phenylmercuric acetate、Captan、Chloranil et al	Schizophrenia	[168]
	Non-cancer drug	4518	50	Disulfiran、Tepoxalin et al	Cancer	[169]

ISSN: 1749-8546