Fig. 5

Expression correlation and clinicopathological significance of DNMT1, miR-34a-5p and FoxM1 in HCC tissues. A–D Immunohistochemistry and in situ hybridization showing the expression level of DNMT1 and FoxM1, and miR-34a-5p in the HCC and paired paracancerous tissues respectively. A Representative images of DNMT1, miR-34a-5p and FoxM1 expressions, and (B–D) Statistical analysis results of DNMT1, miR-34a-5p and FoxM1 expressions. E–G Correlation between alterations for DNMT1, miR-34a-5p, and FoxM1 in the HCC tissues. E Representative IHC images of low and high expression of DNMT1, FoxM1, and miR-34a-5p the HCC tissues. F, G Statistical analysis results of correlation between DNMT1 and miR-34a-5p expressions, and miR-34a-5p and FoxM1 expressions (Pearson correlation test). H Survival analysis of HCC patients. Kaplan–Meier survival analysis of overall survival (top) and disease-free survival (bottom) for 92 HCC patients based on the expression levels of DNMT1, miR-34a-5p, FoxM1, or a combination of three molecules. The log-rank test was used to calculate the P value. Scale bars = 50 μm