Prescriptions | Composition | TCM mechanism | Improved epilepsy-related indicators in animal model |
---|---|---|---|
Dian Xian Ning | Saruma Henryi, Pharbitidis Semen, Uncariae Ramulus Cum Uncis, Acori Tatarinowii Rhizoma, Nardostachyos Radix et Rhizoma, EuphorbiaeSemen, Menthae Haplocalycis Herba, Valerianae Radix et Rhizoma | Clear phlegm and open orifice, extinguish Feng and calm the mind | (1) Inhibit the epileptic behaviors in KA rat model (2) Alleviate the severity in pilocarpine rat model (3) Prolong the latency to seizure in PTZ mice model (4) Reduce the mortality in PTZ mice model (5) Prolong the latency to seizure in PTZ zebrafish model |
Ding Xian Pill | Polygalae Radix, Acori Tatarinowii Rhizoma, Salviae miltiorrhizae Radix et Rhizoma, Pinelliae Rhizoma, Citri Reticulatae Pericarpium, Fritillariae Cirrhosae Bulbus, Poria, Ophiopogonis Radix, Arisaema Cum Bile, Bombyx Batryticatus, Scorpio, Gastrodiae Rhizoma, Cinnabaris, Succinum, Poria Cum Ligno Hospite, Glycyrrhizae Radix et Rhizoma, Zingiberis Rhizoma Recens | Remoe phlegm and extinguish Feng, induce resuscitation and calm the mind | (1) Alleviate the seizure severity in PTZ rat model |
Xingnaojing Injection | Moschus, Borneol, Gardeniae Fructus, Curcumae Radix | Open the brain orifices, awake the brain, and purge the fire | (1) Shorten the durations of generalized tonic–clonic seizures in the MES mice model (2) Prolong the latency to generalized myo-clonic seizures in the PTZ mice (3) Inhibit the seizure stages, prolong the latency to the first occurrence of both absence and generalized seizures, shorten the seizure durations, decrease the numbers of generalized seizures in the KA mice model |