Fig. 8

YAP is the key target of CS-IVa. A The schematic diagram of the molecular docking of CS-IVa with YAP, shown as the 3D diagram. The ribbon and stick structure displays the predicted bonds between CS-IVa and YAP. B The schematic diagram of the molecular docking of CS-IVa with TEAD2, shown as the 3D diagram. The ribbon and stick structure displays the predicted bonds between CS-IVa and TEAD2. C Response value of interaction between CS-IVa and YAP on CM5 chip. D Affinity fitting curves corresponding to reporting points of gradient concentrations. E The stability of the YAP protein was evaluated by CETSA at temperatures ranging from 45 to 75 °C in the presence and absence of CS-IVa