Fig. 8

SQWCF inhibited the PI3K-AKT and MAPK signaling pathways and induced downstream apoptosis pathway. A–B The common enrichment pathways between network pharmacology, transcriptomics, and proteomics. C–D Western blot analysis of the protein expression levels of p-PI3K/PI3K, p-AKT/AKT, p-ERK/ERK, p-JNK/JNK, and p-p38 MAPK/p38 MAPK. E–F Western blot analysis of the protein expression levels of Bad, Bcl-2, Bax, caspase3, cleaved-caspase3, PARP, and cleaved-PARP. G TUNEL staining of the tumor tissues. Data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, NS, no significant