Table 7 Signaling pathway of phytomedicine for HAG

1

(16 types)

NF-κB

Persicaria capitata, Korean Propolis, Juglans regia L., Angelica keiskei, Artemisia capillaris Thunb., Camellia sinensis L., Chaenomeles speciosa total triterpenoids, Neutral corn protein hydrolysate, Artemisinin, Artesunate, Dihydroartemisinin, Curcumin, Capsaicin, Piperine, Caffeic Acid Phenethyl Ester, Sophora alopecuroides L. total alkaloids

2

(4 types)

JAK/STAT3

Juglans regia L., Licorice, Artemisia capillaris Thunb.,

Camellia sinensis L

3

(3 types)

MAPK

Alpinia officinarum Hance, Quercetin, Palmatine

4

(2 types)

TLR4/MyD88

Chaenomeles speciosa total triterpenoids,

Neutral corn protein hydrolysate

5

(2 types)

NLRP3/Caspase-1

Persicaria capitata, Chaenomeles speciosa total triterpenoids

6

(1 type)

PI3K/AKT

Persicaria capitata

7

(1 type)

NRF2/HO-1

Juglans regia L

1

(3 pathways)

NF-κB, PI3K/AKT, NLRP3/Caspase-1

Persicaria capitata

NF-κB, JAK/STAT3, NRF2/HO-1

Juglans regia L

NF-κB, TLR4/MyD88, NLRP3/Caspase-1

Chaenomeles speciosa total triterpenoids

2

(2 pathways)

NF-κB, JAK/STAT3

Artemisia capillaris Thunb.,

Camellia sinensis L

NF-κB, TLR4/MyD88

Neutral corn protein hydrolysate