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Fig. 8 | Chinese Medicine

Fig. 8

From: Electroacupuncture at ST25 mediated glial cells pruning of pancreatic TRPV1 neural synapse responds to neuropathy-associated beta cell dysfunction

Fig. 8

The “Receptor Depletion” hypothesis: The evolution of the transient receptor potential vanillin-1 (TRPV1) receptors in Type 2 Diabetes (T2DM). The transient receptor potential vanillin-1 (TRPV1) positive neurons containing CGRP can control the pancreatic β cells. They form a feedback loop formed which is affected by glial cells and inflammatory cytokines. After continuous chronic stimulation, β cell function was seriously impaired and insulin secretion decreased. At this time, TRPV1 receptor will be inactivated, affecting CGRP secretion and aggravating T2DM. INS, insulin; INsR, insulin receptor; CGRP, calcitonin gene-related peptide; GDNF, glial cell-derived neurotrophic factor; IL-1β, interleukin-1β; IL-10, interleukin-10

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Chinese Medicine

ISSN: 1749-8546

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