Fig. 5

Effects of ILA on motor function, dopaminergic neuronal survival, and their correlation with muscle metabolites in MPTP-induced PD mice. A Experimental design. B Latency to fall off the rotating rod. C Number of rearing in the cylinder test. D Number of entries into the center zone recorded in the OF test. E Fluorescence raw traces of HT-22 cells expressing GCaMP6s during laser exposure. F dF/F0 graph of GCaMP6s-expressing HT-22 cells under laser irradiation at 60 Hz, with wavelengths of 830 nm and 650 nm (830 nm: −0.66 ± 0.29%, 650 nm: −0.81 ± 0.46% n = 13 cells). G Heatmap demonstrating the correlations of muscle metabolites and behavioral test results. H–J Bar graphs demonstrating the relative abundance of glucose, galactose, and O-phosphoethanolamine, along with their correlation with behavioral test results. Data are shown as the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001