Table 1 The role of single components of natural products in promoting LR
Categories | Monomers | Chemical structures | Effects |
|---|---|---|---|
Dioscin |
| ALT, AST↓ PCNA↑ Notch1↑ Jagged1↑ Cyclins↑ CDK4, CDK2↑ | |
Saponin | Panax notoginseng saponins |
| ALT, AST↓ PCNA↑ PI3K, Akt↑ mTOR ↑ |
Baicalin |
| ALT, AST↓ PCNA↑ cyclin D1↑ IL-1β, IL-18↑ | |
Flavonoid | Dihydromyricetin |
| ALT, AST↓ SOD↑ PCNA↑ IL-1β, IL-6, TNF-α↓ cytochrome c↓ caspase -8、3、6、9↓ |
Quercetin |
| PCNA↑ SOD, GSH↑ MDA↓ | |
Phenols | Curcumin |
| PCNA↑ SOD, GSH↑ MDA↓ |
Resveratrol |
| ALT, AST↓ CYP2E1, CYP3A11,CYP1A2↓ PCNA↑ CyclinD1↑ CDK4↑ | |
Schisandrol B |
| HGF, EGF↑ IL-6↑ cyclinD1↑ PCNA↑ P53, p21↓ Bcl-2↑ | |
Rosmarinic acid |
| ALT, AST ALP↓ PCNA↑ | |
Terpenoids | Ursolic acid |
| DNA↑ CyclinD1↑ CyclinE↑ C/EBPβ↑ |
Oleanolic acid |
| PCNA↑ CyclinD1↑ CyclinE1↑ FOXO, RBL2, CDKN1B↓ | |
Geraniol |
| ALT↓ TNF-α, IL-6↑ |
